陈柱成实验室
Chen Zhucheng Laboratory
Li L#, Chen K#, Sia Y#, Hu P, Ye Y, Chen Z*. Structure of the ISW1a complex bound to the dinucleosome. Nat Struct Mol Biol. 2024 Jan 4. doi: 10.1038/s41594-023-01174-6.
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Chen K#, Yuan J#, Sia Y, Chen Z*. Mechanism of action of the SWI/SNF family complexes. Nucleus. 2023 Dec;14(1):2165604. doi: 10.1080/19491034.2023.2165604. (invited review)
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Yuan J#, Chen K#, Zhang W, Chen Z*. Structure of human PBAF chromatin remodeling complex bound to a nucleosome. Nature, 605(7908):166-171, 2022.
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Qu K#, Chen K#, Wang H#, Li X*, Chen Z*. Structure of the NuA4 acetyltransferase complex bound to the nucleosome. Nature, 2022. https://www.nature.com/articles/s41586-022-05303-x
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Wang L#, Chen K#, Chen Z*. Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. Nature Comm. 12 (1):4058, 2021.
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He Z#, Chen K#, Ye Y#, Chen Z*. Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity. Cell Discovery. 7(1): 28, 2021.
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Li L, Yan L, Chen Z. Reply to: Histone dynamics play a critical role in SNF2h-mediated nucleosome sliding. Nat. Struct. Mol. Biol. 28(7):552-553, 2021.
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Pan H, Guan R, Zhao R, Ou G, Chen Z. Mechanistic insights into central spindle assembly mediated by the centralspindlin complex. PNAS 118(40): e2112039118, 2021.
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Yan L, and Chen Z*. A Unifying Mechanism of DNA Translocation Underlying Chromatin Remodeling. Trends Biochem. Sci. 45(3):217-227, 2020.（invited review）
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Chen M#, Pan H#, Sun L#, Shi P#, Zhang Y, Li L, Huang Y, Chen J, Jiang P, Fang X, Wu C, Chen Z*. Structure and regulation of human epithelial cell transforming 2 protein. PNAS 117(2):1027-1035, 2020.
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Ye Y#, Wu H#, Chen K, Clapier CR, Verma N, Zhang W, Deng H, Cairns BR＊, Gao N＊, Chen Z＊. Structure of the RSC complex bound to the nucleosome. Science, 366(6467):838-843, 2019.
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Li M#, Xia X#, Tian Y#, Jia Q#, Liu X#, Ying L, Li M＊, Li X＊, Chen Z*. Mechanism of DNA translocation underlying chromatin remodeling by Snf2. Nature, 567(7748): 409-413, 2019.
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Yan L#, Wu H#, Li X, Gao N*, Chen Z*. Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nat. Struct. Mol. Biol. 26(4):258-266, 2019.
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Huang H, Luo Z, Qi S, Huang J, Xu P, Wang X, Gao L, Li F, Wang J, Zhao W, Gu W, Chen Z, Dai L, Dai J, Zhao Y. Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 28(1):111-125, 2018.
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Liu X#, Li M#, Xia X#, Li X＊, Chen Z*. Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure. Nature 544 (7651):440-445, 2017.
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Guan R#, Zhang L#, Su Q P, Mickolajczyk KJ, Chen GY, Hancock WO, Sun Y. Zhao Y, Chen Z*. Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin. Nature Comm. 8:14951, 2017.
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Yan L#, Wang L#, Tian Y, Xia X, Chen Z*. Structure and regulation of the chromatin remodeller ISWI. Nature 540(7633):466-469, 2016.
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Xu P#, Li C#, Chen Z, Jiang S, Fan S, Wang J, Dai J, Zhu P*, Chen Z*. The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism. Mol. Cell. 63 (6):965-75, 2016.
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Qin Y, Tan C, Lin, J, Qin Q, He J, Wu, Q, Cai Y, Chen Z*, Dai J*. EcoExpress – a highly efficient construction and expression of multicomponent protein complexes in Escherichia coli. ACS Synth Biol. 5(11):1239-1246, 2016.
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Cao T, Sun L, Jiang Y, Huang S, Wang J, Chen Z*. Crystal structure of a nuclear actin ternary complex. PNAS.113(32): 8985-90, 2016.
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Xia X#, Liu X#, Li T, Fang, X, Chen Z*. Structure of chromatin remodeller Swi2/Snf2 in the resting state. Nat. Struct. Mol. Biol. 23(8):722-9, 2016.
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Xu X#, Lin A#, Zhou C#, Blackwell SR, Zhang Y, Wang Z, Feng Q, Guan R, Hanna MD, Chen Z*, Xiao W*. Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1. Nucleic Acids Res. 44(11): 5231-45, 2016.
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Mi N, Chen Y, Wang S, Chen M, Zhao M, Yang G, Ma M, Su Q, Luo S, Shi J, Xu J, Guo Q, Gao N, Sun Y, Chen Z*, Yu L*. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nat. Cell Biol. 17(9):1112-23,2015
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Tian D, Diao M, Jiang Y, Sun L, Zhang Y, Chen Z, Huang S, Ou G. Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton. Curr Biol. 25(9):1135-45, 2015.
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Sun L#, Guan R#, Lee IJ, Liu Y, Chen M, Wang J, Wu JQ, Chen Z*. Mechanistic insights into the anchorage of the contractile ring by anillin and Mid1. Dev. Cell. 33(4):413-26, 2015.
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Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, Henry L, Grishin NV, Bogdan S, Rosen MK. The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton Cell. 156(1-2):195-207, 2014.
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Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick DR, Chen Z, Rosen MK. The bacterial effector VopL organizes actin into filament-like structures. Cell. 155(2):423-34, 2013.
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Chen Z., Borek D., Patrick S.B., Gomez T.S., Metlagel Z., Ismail A., Umetani J. Billadeau D.D., Otwinoski Z. and Rosen M.K. Structure and control of the actin regulatory WAVE complex. Nature, 468,(7323),533-538, 2010.
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Chen Z., Yang H., and Pavletich N.P. Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures. Nature, 453 (7194), 489-494, 2008.
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Chen Z, Ost T.W., and Schelvis J.P. Phe 393 Mutants of Cytochrome P450 BM3 with Modified Heme Redox Potentials Have Altered heme Vinyl and Propionated Conformations. Biochemistry 43 (7), 1798-1808, 2004.
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Chen Z., Wang L.H. and Schelvis J.P. Resonance Raman Investigation of the Interaction of Thromboxane Synthase with Substrate Analogues. Biochemistry 42 (9), 2452-2451, 2003.
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Zheng J., Chen Z., and Liu Z. Atomic Force Microscopy-Based Nanolithography on Silicon Using Colliod Gold Nanoparticles as a Nanooxidation Mask. Langmuir, 16 (24), 9873-9676, 2000.
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010-62792447
Mailing address：A315, Biomedical Building, Tsinghua University, Beijing, 100084
Email：zhucheng_chen@tsinghua.edu.cn
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