We mainly study the structure, mechanism and function of chromatin-regulating molecular machines. DNA tightly wraps around histones to form nucleosomes, the basic repeating units of chromatin. However, the assembly of nucleosome and the formation of compact chromatin hinder the reading of genetic information in DNA. Epigenetic factors, such as DNA methylases, histone-modifying enzymes, chromatin remodeling complexes, and non-coding RNAs, play a central role in shaping chromatin structures and controlling gene expression, cell fate determination, and human diseases.
We resolved the structure of Snf2 motor bound to the nucleosome in the ground state, ADP state, ADP-BEFX state, and identified the key DNA movement states during chromatin remodeling.More
The structure of the human PBAF complex bound to the nucleosome reveals the structural features that distinguish PBAF from BAF and the mechanism by which the motor recognizes nucleosomes.More
The structure of the yeast acetyltransferase NuA4 holoenzyme bound to the nucleosome elucidates how NuA4 is assembled and the mechanism of nucleosome recognition and transcriptional co-activation by NuA4.More